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In the wake of the tumultuous geopolitical events of the past two years, it has become increasingly evident that the global security environment is undergoing rapid transformations, necessitating a more nuanced approach both within and outside the transatlantic security community. This reality also holds for the CBRN defence domain, in which the JCBRN Defence COE plays a crucial role, providing recognized expertise and experience to NATO and its Parners. Therefore, it comes as no surprise that the 2023 JCBRN Defence COE Annual Conference, held in Prague from October 2 to 4, 2023, focused on issues of paramount significance to the Alliance, encompassing the overarching theme of "CBRN Defence and Resilience in the light of the current security environment & future challenges."